User profiles for W. Joost Wiersinga

W. Joost Wiersinga

Professor of Medicine, Amsterdam UMC, University of Amsterdam
Verified email at amsterdamumc.nl
Cited by 37260

Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review

WJ Wiersinga, A Rhodes, AC Cheng, SJ Peacock… - Jama, 2020 - jamanetwork.com
Importance The coronavirus disease 2019 (COVID-19) pandemic, due to the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a worldwide sudden …

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

…, MA Weigand, SB Flohé, WJ Wiersinga… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

[HTML][HTML] A guide to immunotherapy for COVID-19

…, H Leavis, R van Crevel, JJ Engel, WJ Wiersinga… - Nature medicine, 2022 - nature.com
Immune dysregulation is an important component of the pathophysiology of COVID-19. A
large body of literature has reported the effect of immune-based therapies in patients with …

[HTML][HTML] Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016

…, T Van der Poll, JL Vincent, WJ Wiersinga… - Intensive care …, 2017 - Springer
Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

…, C Schorr, S Simpson, WJ Wiersinga… - Critical care …, 2021 - journals.lww.com
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

…, R Derking, I Bontjer, NA Kootstra, WJ Wiersinga… - Science, 2020 - science.org
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
had a large impact on global health, travel, and economy. Therefore, preventative and …

[PDF][PDF] The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Melioidosis

WJ Wiersinga, BJ Currie… - New England Journal of …, 2012 - Mass Medical Soc
Melioidosis | NEJM Skip to main content NEJM Group Follow Us Facebook Twitter Instagram
YouTube LinkedIn Prepare to become a physician, build your knowledge, lead a health care …

[HTML][HTML] The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

…, C Belzer, WM de Vos, T van der Poll, WJ Wiersinga - Gut, 2016 - gut.bmj.com
Objective Pneumonia accounts for more deaths than any other infectious disease worldwide.
The intestinal microbiota supports local mucosal immunity and is increasingly recognised …

[HTML][HTML] Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei

WJ Wiersinga, T Van der Poll, NJ White… - Nature Reviews …, 2006 - nature.com
Burkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis,
a severe disease that is endemic in areas of Southeast Asia and Northern Australia. …