User profiles for W.T. McNicholas

Walter McNicholas

School of Medicine, University College Dublin
Verified email at ucd.ie
Cited by 35622

Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities

WT McNicholas, MR Bonsignore… - European …, 2007 - Eur Respiratory Soc
Considerable evidence is available in support of an independent association between
obstructive sleep apnoea syndrome (OSAS) and cardiovascular disease, which is particularly …

Obstructive sleep apnoea syndrome

P Lévy, M Kohler, WT McNicholas, F Barbé… - Nature reviews Disease …, 2015 - nature.com
… Finally, combining different treatment modalities such as CPAP and weight control is
beneficial, but need to be evaluated in randomized controlled trials. For an illustrated summary of …

Hypoxemia in patients with COPD: cause, effects, and disease progression

…, PD Mitchell, WT McNicholas - International journal of …, 2011 - Taylor & Francis
… been shown to correlate with the degree of muscle dysfunction in COPD, Citation96 while
NFκB activation appears to occur in the skeletal muscle of COPD patients with low body weight

Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome

S Ryan, CT Taylor, WT McNicholas - Circulation, 2005 - Am Heart Assoc
Background— Obstructive sleep apnea syndrome (OSAS), characterized by intermittent
hypoxia/reoxygenation (IHR), is an independent risk factor for cardiovascular disease. We …

Long-term effects of nasal continuous positive airway pressure therapy on cardiovascular outcomes in sleep apnea syndrome

LS Doherty, JL Kiely, V Swan, WT McNicholas - Chest, 2005 - Elsevier
… A specially designed questionnaire was also posted to each patient requesting details of
height and weight, the use of CPAP therapy, Epworth sleepiness scale score, smoking history, …

Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation

…, CT Taylor, WT McNicholas - European Respiratory …, 2009 - Eur Respiratory Soc
There is increasing evidence that intermittent hypoxia plays a role in the development of
cardiovascular risk in obstructive sleep apnoea syndrome (OSAS) through the activation of …

Predictive value of clinical features for the obstructive sleep apnoea syndrome

PC Deegan, WT McNicholas - European Respiratory Journal, 1996 - Eur Respiratory Soc
The advantage of being a National Referral Centre for patients with suspected obstructive
sleep apnoea (OSA) was used to seek clinical factors predictive of OSA, and thus determine if …

Pathophysiology of obstructive sleep apnoea

PC Deegan, WT McNicholas - European Respiratory Journal, 1995 - Eur Respiratory Soc
The pathophysiology of obstructive sleep apnoea (OSA) is complex and incompletely
understood. A narrowed upper airway is very common among OSA patients, and is usually in …

Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?

…, CT Taylor, WT McNicholas - Postgraduate medical …, 2009 - academic.oup.com
Obstructive sleep apnoea syndrome (OSAS) is a highly prevalent disease and is recognised
as a major public health burden. Large-scale epidemiological studies have demonstrated …

Predictors of elevated nuclear factor-κB–dependent genes in obstructive sleep apnea syndrome

S Ryan, CT Taylor, WT McNicholas - American journal of respiratory …, 2006 - atsjournals.org
Background: Circulating nuclear factor-κB (NF-κB)–dependent genes, particularly tumor
necrosis factor-α (TNF-α), are elevated in obstructive sleep apnea syndrome (OSAS) and likely …