[HTML][HTML] T2-high asthma phenotypes across lifespan

…, H Biller, KI Gaede, X Bovermann… - European …, 2022 - Eur Respiratory Soc
Rationale In adults, personalised asthma treatment targets patients with type 2 (T2)-high and
eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in …

[HTML][HTML] IgA+ memory B-cells are significantly increased in patients with asthma and small airway dysfunction

…, H Biller, KI Gaede, X Bovermann… - European …, 2022 - Eur Respiratory Soc
Background Comprehensive studies investigated the role of T-cells in asthma which led to
personalised treatment options targeting severe eosinophilic asthma. However, little is known …

[HTML][HTML] Multicentre feasibility of multiple-breath washout in preschool children with cystic fibrosis and other lung diseases

…, R Minso, I Rudolf, C Stolpe, X Bovermann… - ERJ Open …, 2020 - Eur Respiratory Soc
Background Multiple-breath washout (MBW)-derived lung clearance index (LCI) detects early
cystic fibrosis (CF) lung disease. LCI was used as an end-point in single- and multicentre …

Accelerated dose escalation with three injections of an aluminum hydroxide-adsorbed allergoid preparation of six grasses is safe for patients with moderate to severe …

MV Kopp, X Bovermann, L Klimek - International archives of allergy and …, 2020 - karger.com
Only few data on safety during high-dose, accelerated escalation schedules during subcutaneous
allergen immunotherapy (AIT) are available. The aim of this study was to assess the …

Accelerated dose escalation with 3 injections of an aluminum hydroxide-adsorbed allergoid preparation of 6 grasses is safe for children and adolescents with …

X Bovermann, I Ricklefs, C Vogelberg… - International archives of …, 2021 - karger.com
A high-dose, accelerated escalation schedule during subcutaneous allergen-specific
immunotherapy (AIT) is safe and well-tolerated in adults. However, there are no data in children …

[HTML][HTML] Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE cohort

…, M Abdo, H Biller, KI Gaede, X Bovermann… - Journal of Allergy and …, 2023 - Elsevier
Background The Asthma Severity Scoring System (ASSESS) quantifies asthma severity in
adolescents and adults. Scale performance in children younger than 12 years is unknown. …

The lung clearance ratio: a ventilation inhomogeneity index less sensitive to breathing pattern

M Curdy, X Bovermann, S Yammine, P Latzin, F Wyler - 2023 - Eur Respiratory Soc
Multiple-breath washout (MBW) is a method to measure ventilation inhomogeneity (VI), defined
by the lung clearance index (LCI). Breathing pattern and changes in functional residual …

A Mild Case of Jeune Syndrome Associated with a Recurrent Missense Variant in DYNC2H1: Confirmation of a Genotype-Phenotype Correlation

MA Oestreich, F Keller, X Bovermann… - Klinische …, 2024 - thieme-connect.com
Asphyxiating thoracic dystrophy type Jeune is a rare, potentially fatal, autosomal recessive
skeletal dysplasia characterized by a small and narrow thorax, lung hypoplasia, limb …

Tollip and Muc5b Modulate the Effect of Ambient No2 on Respiratory Symptoms in Infancy

…, CRDS Sena, R Steinberg, X Bovermann… - Available at SSRN … - papers.ssrn.com
Background Current knowledge suggests that the gene region containing MUC5B and TOLLIP
plays a role in airway defence and airway inflammation, and hence respiratory disease. It …

Automated quality control for spirometry as a tool for faster and more objective results

X Bovermann, LH Dac, M Curdy, N Meuwly, C Streibel… - 2023 - Eur Respiratory Soc
Background: Spirometry is the most commonly used lung function test in pediatric pulmonology.
Valid outcome values require correct execution of breathing maneuvers, which can be …