[HTML][HTML] Fraction of MHCII and EpCAM expression characterizes distal lung epithelial cells for alveolar type 2 cell isolation

…, A Sato, K Tanimura, K Uemasu, Y Hamakawa… - Respiratory …, 2017 - Springer
Backgound Alveolar type 2 (AT2) cells play important roles in maintaining adult lung homeostasis.
AT2 cells isolated from the lung have revealed the cell-specific functions of AT2 cells. …

[HTML][HTML] Associations of pulmonary and extrapulmonary computed tomographic manifestations with impaired physical activity in symptomatic patients with chronic …

Y Hamakawa, N Tanabe, H Shima, K Terada… - Scientific Reports, 2022 - nature.com
In patients with chronic obstructive pulmonary disease (COPD), emphysema, airway disease,
and extrapulmonary comorbidities may cause various symptoms and impair physical …

Accelerated loss of antigravity muscles is associated with mortality in patients with COPD

…, N Tanabe, K Hasegawa, K Uemasu, Y Hamakawa… - Respiration, 2020 - karger.com
Background: Low antigravity muscle mass is strongly associated with poor prognosis in
patients with chronic obstructive pulmonary disease (COPD). However, the significance of …

Serine protease imbalance in the small airways and development of centrilobular emphysema in chronic obstructive pulmonary disease

…, K Hasegawa, T Mizutani, Y Hamakawa… - American Journal of …, 2020 - atsjournals.org
Epithelial dysfunction in the small airways may cause the development of emphysema in
chronic obstructive pulmonary disease. C/EBPα (CCAAT/enhancer binding protein-α), a …

Effects of sarcopenia on ventilatory behavior and the multidimensional nature of dyspnea in patients with chronic obstructive pulmonary disease

…, K Terada, N Tanabe, H Shima, Y Hamakawa… - Journal of the American …, 2021 - Elsevier
Objectives This study tested the hypothesis that sarcopenia, a common extrapulmonary
feature of chronic obstructive pulmonary disease (COPD), can affect ventilatory behavior, and …

Gastroesophageal reflux symptoms and nasal symptoms affect the severity of bronchitis symptoms in patients with chronic obstructive pulmonary disease

…, K Tanimura, Y Fuseya, K Uemasu, Y Hamakawa… - Respiratory …, 2018 - Elsevier
Background Cough and sputum production (symptoms of bronchitis) are common in chronic
obstructive pulmonary disease (COPD). Extrapulmonary comorbidities, such as …

[HTML][HTML] Preliminary study of assessing cognitive impairment in older patients with chronic obstructive pulmonary disease by using a cognitive functional assessment …

…, A Uchiumi, S Sato, Y Hamakawa… - Multidisciplinary …, 2023 - ncbi.nlm.nih.gov
Background Unique cognitive impairments related to chronic obstructive pulmonary diseases
(COPD) have been increasingly reported. Considering the dementia risk and medication …

Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia: A 6‐year follow‐up study

…, A Sato, N Tanabe, K Hasegawa, Y Hamakawa… - …, 2019 - Wiley Online Library
Background and objective Chronic respiratory failure (CRF) with hypoxaemia is an important
pathophysiology in patients with chronic obstructive pulmonary disease (COPD), and …

Perspectives on end-of-life treatment among patients with COPD: A multicenter, cross-sectional study in Japan

…, K Hasegawa, K Uemasu, Y Hamakawa… - COPD: Journal of …, 2019 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality. Since patients
with severe COPD may experience exacerbations and eventually face mortality, advanced …

Expiratory central airway collapse and symptoms in smokers

N Tanabe, K Terada, H Shima, Y Hamakawa… - Respiratory …, 2021 - Elsevier
Background The prevalence and clinical impacts of expiratory central airway collapse (ECAC)
in smokers remain controversial. Although studies have shown associations of ECAC with …