Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications

  1. Sarah L. Gaffen
  1. Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
  1. Correspondence: sarah.gaffen{at}pitt.edu
  • 1 Present address: The Francis Crick Institute, London NW1 1AT, United Kingdom.

Abstract

The cytokines of the interleukin 17 (IL-17) family play a central role in the control of infections, especially extracellular fungi. Conversely, if unrestrained, these inflammatory cytokines contribute to the pathology of numerous autoimmune and chronic inflammatory conditions. Recent advances have led to the approval of IL-17A-blocking biologics for the treatment of moderate to severe plaque psoriasis, but much remains to be understood about the biological functions, regulation, and signaling pathways downstream of these factors. In this review, we outline the current knowledge of signal transduction and known physiological activities of IL-17 family cytokines. We will highlight in particular the current understanding of these cytokines in the context of skin manifestations of disease.



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      1. Cold Spring Harb. Perspect. Biol. 10: a028522 Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved

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