The impact of the first COVID-19 surge on Severe Asthma Patients in the UK. Which is worse: The virus or the lockdown?

  1. Steven J. Smith1,
  2. John Busby2,
  3. Liam G. Heaney2,
  4. Paul E. Pfeffer3,
  5. David J. Jackson4,5,
  6. Freda Yang1,
  7. Stephen J. Fowler6,
  8. Andrew Menzies-Gow7,
  9. Elfatih Idris8,
  10. Thomas Brown9,
  11. Robin Gore10,
  12. Shoaib Faruqi11,
  13. Paddy Dennison12,
  14. James W. Dodd13,
  15. Simon Doe14,
  16. Adel H. Mansur15,
  17. Radhika Priyadarshi3,
  18. Joshua Holmes2,
  19. Andrew Hearn4,5,
  20. Hamsa Al-Aqqad6,
  21. Lola Loewenthal7,
  22. Angela Cooper8,
  23. Lauren Fox9,
  24. Mayurun Selvan10,
  25. Michael G. Crooks11,
  26. Alison Thompson12,
  27. Daniel Higbee13,
  28. Michelle Fawdon14,
  29. Vishal Nathwani15,
  30. LeanneJo Holmes6 and
  31. Rekha Chaudhuri1
  32. on behalf of the UK Severe Asthma Registry
  1. 1Gartnavel General Hospital and University of Glasgow, Glasgow, UK
  2. 2Queens University, Belfast, UK
  3. 3St Bartholomew's Hospital, Bart's Health NHS Trust, London & Queen Mary University of London, London, UK
  4. 4Guys and St Thomas's Hospitals, London, UK
  5. 5Guy's and St Thomas’ NHS Trust, London & King's College London, London, UK
  6. 6School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK
  7. 7Royal Brompton Hospital, London, UK
  8. 8Royal Stoke University Hospital, Stoke, UK
  9. 9Queen Alexandra Hospital, Portsmouth, UK
  10. 10Addenbrooke's Hospital, Cambridge, UK
  11. 11Hull University Teaching Hospital, Hull, UK
  12. 12University Hospital Southampton, Southampton, UK
  13. 13Academic respiratory unit, University of Bristol & North Bristol Lung Centre, Southmead Hospital, Bristol, UK
  14. 14Royal Victoria Infirmary, Newcastle, UK
  15. 15Heartlands Hospital, University Hospitals Birmingham, Birmingham, UK
  1. Prof. Rekha Chaudhuri, Gartnavel General Hospital and University of Glasgow, Glasgow, UK, 1053 Great Western Road, Glasgow G120YN. E-mail: rekha.chaudhuri{at}ggc.scot.nhs.uk

Footnotes

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Conflict of interest: Dr. Smith has nothing to disclose.

Conflict of interest: Dr. Busby has nothing to disclose.

Conflict of interest: L.G. Heaney reports sponsorship for attending international scientific meetings from AstraZeneca, Boehringer Ingelheim, Chiesi, GSK and Napp Pharmaceutical; lecture fees and advisory boards fees from Novartis, Hoffman la Roche/Genentech Inc., Sanofi, GlaxoSmithKline, AstraZeneca, Evelo Biosciences, Teva, Theravance and Circassia; institutional grant funding from Medimmune, Novartis UK, Roche/Genentech Inc. and GlaxoSmithKline. He is Academic Lead for the Medical Research Council Stratified Medicine UK Consortium in Severe Asthma, which involves industrial partnerships with Amgen, Genentech/Hoffman la Roche, AstraZeneca, Medimmune, GlaxoSmithKline, Aerocrine and Vitalograph.

Conflict of interest: P.E. Pfeffer reports grants and travel fees from GlaxoSmithKline, and speaker and travel fees from AstraZeneca, outside the submitted work.

Conflict of interest: Dr. Jackson has nothing to disclose.

Conflict of interest: J.F. Yang reports speakers fees and travel support from AstraZeneca, and travel support from GlaxoSmithKline, outside the submitted work.

Conflict of interest: Dr. Fowler has nothing to disclose.

Conflict of interest: Dr. Menzies-Gow reports grants and personal fees from Astra Zeneca, personal fees from Glaxo SmithKline, personal fees from Sanofi, personal fees from Novartis, personal fees and non-financial support from Teva, personal fees from Vectura, outside the submitted work.

Conflict of interest: Dr. IDRIS has nothing to disclose.

Conflict of interest: T. Brown reports grants from Asthma UK and Innovate UK; personal fees and nonfinancial support from AstraZeneca, grants, speaker fees and travel expenses from GlaxoSmithKlines; speaker fees, advisory board fees, conference fees and travel expenses from Teva; conference fees and travel expenses from Napp Pharmaceuticals; and personal fees and nonfinancial support from Novartis, all outside the submitted work.

Conflict of interest: R. Gore reports speaker fees from GSK, Astra Zeneca and UK outside the submitted work.

Conflict of interest: Dr. Faruqi has nothing to disclose.

Conflict of interest: Dr. Dennison has nothing to disclose.

Conflict of interest: J.W. Dodd reports honoraria for educational meetings and expert advisory boards from Chiesi, AstraZeneca, Boehringer Ingelheim and GlaxoSmithKline; and registration, travel and accommodation for international conferences from Chiesi, outside the submitted work.

Conflict of interest: Dr. Doe has nothing to disclose.

Conflict of interest: A.H. Mansur reports personal and departmental fees for talks, advisory board, grants for service development, sponsorship to attend conferences from AstraZeneca, GSK, Novartis, Chiesi, Napp, Sanofi and Teva, outside the submitted work.

Conflict of interest: Dr. Priyadarshi has nothing to disclose.

Conflict of interest: Mr. Holmes has nothing to disclose.

Conflict of interest: Dr. Hearn has nothing to disclose.

Conflict of interest: Mrs. Al-Aqqad has nothing to disclose.

Conflict of interest: Lola Loewenthal

Conflict of interest: Dr. Cooper has nothing to disclose.

Conflict of interest: Lauren Fox has nothing to disclose.

Conflict of interest: Dr. Selvan has nothing to disclose.

Conflict of interest: Dr. Crooks has nothing to disclose.

Conflict of interest: Alison Thompson

Conflict of interest: Dr. Higbee has nothing to disclose.

Conflict of interest: Michelle Fawdon

Conflict of interest: Dr. Nathwani has nothing to disclose.

Conflict of interest: L. Holmes reports speaker fees from Novartis and AstraZeneca, and conference sponsorship from Teva, outside the submitted work.

Conflict of interest: R. Chaudhuri reports advisory board meetings, research grant, speaker fees and conference travel support from AstraZeneca, advisory board meeting and speaker fees from GSK, advisory board meeting fees and nonfinancial support from Teva, advisory board meeting and speaker fees from Novartis, advisory board meeting fees and nonfinancial support from Chiesi, and conference travel support from Napp Pharmaceuticals, outside the submitted work.

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  • Received October 22, 2020.
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